Product Name:Diosmin 

Molecular Weight:608.54

CAS No.:520-27-4

Specification:EP/BP/USP

EINECS No.:208-289-7

Bulk density:0.55-0.62g/ml

Assay (HPLC),anhydrous substance:90.0-102.0%

Tap density:0.80-0.85g/ml

Molecular Formula:C₂₈H₃₂O₁₅

Molecular Weight:608.54

Lot Weight:1000kg

Retest date:24 months from date of production

Storage:in an airtight container . Save 30 ℃ the following and keep in dry place&keep away from strong light and heat

Particle Size (Laser particle analyzer):95% Pass 80 mesh; D95<5um, D80<2um;Before granulation 95% <5um, after granulation 80% pass 20-60 mesh.

Usage:Naturally occurring flavonic glycoside; rhamnoglycoside of Diosmetin. Capillary protectant

Description:Diosmin is a semisynthetic phlebotropic drug, a member of the flavonoid family. Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol, It dissolves in dilute solutions of alkali hydroxides.

Test items

Testing specifications

CHARACTERS

Appearance

Greyish-yellow or light yellow hygroscopic powder

Solubility

Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides

IDENTIFICATION（A、B）

Examine the chromatogram obtained in the essay. The principal peak in the chromatogram obtained with the test solution （a）is similar in retention time and size to the principal peak in the chromatogram obtained with the reference solution（a）

TESTS

Iodine

≤ 0.1%

related substances (HPLC)

Impurity A (acetoisovanillone)

≤ 0.5%

Impurity B (hesperidin)

≤ 4.0%

Impurity C (isorhoifolin)

≤ 3.0%

Impurity E (linarin)

≤ 3.0%

Impurity F(diosmetin)

≤ 2.0%

Any other impurity

≤ 1.0%

Total of other impurities and impurity a

≤ 1.0%

Total

≤ 8.5%

Heavy metals 

≤ 20 ppm

Water 

≤ 6.0%

Assay(HPLC), anhydrous substance 

90.0%-102.0%

Residual solvents　

Pyridine

≤ 200ppm

Total plate count

< 1000cfu/g

Yeasts and molds

< 100cfu/g

E. Coliform

Negative in 1g